Researcher: David Gamm

Areas of Research Expertise
  • Cellular and molecular immunology
  • Cornea and conjunctiva
  • Virology
  • Herpes infections
  • Trabecular meshwork cell biology
  • Retinal degeneration
  • Epidemiology
  • Nutritional biochemistry
  • Eye diseases
  • Occular oncology
  • Occular gene therapy
  • Human retinal development
  • Degeneration of photoreceptors and retinal pigment epithelium (RPE)
  • Applications of stem cell biology in the treatment of neurodegenerative diseases
  • Expansion of precursor cells and RPE obtained from prenatal and adult human eyes and determine their capacity to repopulate or rescue photoreceptors in animal models of degeneration
  • Influence of RPE on retinal development
  • Retinitis pigmentosa and macular degeneration
Web Site David Gamm's Department of Ophthalmology and Visual Sciences Website
Curriculum Vitae (CV)
Current/Active Funding
  • NIH, 2010-2016, Mechanisms of retinogenesis in human stem cells
  • Foundation Fighting Blindness, 2013-2016, Co-culture and analysis of neural retina and RPE derived from GMP super donor hiPSC lines
  • WARF, 2012-2020, Laboratory share - Gamm
  • Foundation Fighting Blindness, 2013-2016, Finding elusive RP genes
  • NIH, 2014-2016, Modeling neural development using human iPSCs from TSC patients
  • Research to Prevent Blindness, 2014-2019, Augmenting rod genesis in human pluripotent stem cells/nelson trust award
  • University of Iowa, 2015-2016, Disease mechanisms in Best Disease
  • NIH, 2015-2019, Molecular therapies for lebers congenital amaurosis caused by KCNJ13 mutations
  • Foundation Fighting Blindness, 2014-2017, Production and characterization of patient-specific ips cell models of best disease for therapeutic testing
  • Research to Prevent Blindness, 2014-2016, Optimizing cell transplantation strategies for AMD: Roles of mitochondrial integrity and function in hiPSC-RPE survival
  • Reeves (Carl and Mildred Almen) Foundation, 2015-2016, Reeves Foundation Equipment Grant 2015
  • Choroideremia Research Foundation, Inc., 2016-2017, Production and testing of CHM hiPSC-derived retinal and vascular cells
Issued Patent(s)
  • 9,328,328 - Substantially pure human retinal progenitor, forebrain progenitor, and retinal pigment epithelium cell cultures and methods of making the same, issued May 2016.
USPTO Published Applications
  • 20110081719 - Substantially pure human retinal progenitor, forebrain progenitor, and retinal pigment epithelium cell cultures and methods of making the same, published April 2011.
Recent Publication(s)
  • Report on the National Eye Institute Audacious Goals Initiative: Photoreceptor Regeneration and Integration Workshop. Gamm DM, Wong R; and the AGI Workshop Panelists. Transl Vis Sci Technol. 2015 Nov 17;4(6):2. eCollection 2015 Nov.

  • Pharmacological Modulation of Photoreceptor Outer Segment Degradation in a Human iPS Cell Model of Inherited Macular Degeneration. Singh R, Kuai D, Guziewicz KE, Meyer J, Wilson M, Lu J, Smith M, Clark E, Verhoeven A, Aguirre GD, Gamm DM. Mol Ther. 2015 Nov;23(11):1700-11. doi: 10.1038/mt.2015.141. Epub 2015 Aug 24.

  • VSX2 and ASCL1 Are Indicators of Neurogenic Competence in Human Retinal Progenitor Cultures. Wright LS, Pinilla I, Saha J, Clermont JM, Lien JS, Borys KD, Capowski EE, Phillips MJ, Gamm DM. PLoS One. 2015 Aug 20;10(8):e0135830. doi: 10.1371/journal.pone.0135830. eCollection 2015.

  • Eye muscle surgery for recurrent nystagmus related to head tilt after prior torsional surgery. Kushner BJ, Gamm DM. J AAPOS. 2015 Jun;19(3):211-6. doi: 10.1016/j.jaapos.2015.02.011.

View David Gamm's publications at PubMed.
Recent Artistic Works
  • University of New Mexico, Division of Ophthalmology
  • Harvard University, Department of Ophthalmology
  • University of Texas, Department of Ophthalmology
  • University of Michigan-Ann Arbor
Research Tools
Research Facilities
E-mail Address [email protected]
Phone Number 608-263-6429
Current University UW–Madison
Department Ophthalmology and Visual Sciences
Title Assistant Professor
Other Appointments
Address Line 1 621, T607 Waisman Center
Address Line 2 1500 Highland Avenue
City Madison
State WI
Zip Code 53705
Bachelor's Degree
Master's Degree
PhD Ph.D., University of Michigan-Ann Arbor
Other Degrees M.D., University of Michigan-Ann Arbor, 1998
Technologies Available for Licensing