Wisconsin Discovery Portal

Researcher: Christian Capitini

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Areas of Expertise
  • Preclinical models of allogeneic blood and marrow transplant (allobmt) to cure pediatric cancers
  • Improve graft-versus-tumor (gvt) effects using adoptive cellular therapies, like t cell and natural killer (NK) cell infusions, and antibody-based approaches that have potential to be translated into the clinic
  • Reduce or eliminate graft-versus-host-disease (GVHD) through modulation of antigen presenting cells
  • Methods to improve the GVT effect
  • Basic, translational and clinical research of pediatric cancers
  • Adoptive cell therapies (NK cell and CAR T cell infusions)
  • Models of bone marrow transplant
  • Graft-versus-host-disease
  • Cancer vaccines
  • Antigen presenting cells
Web Site Christian Capitini's Department of Pediatrics Website
Curriculum Vitae (CV)
Issued Patent(s)
USPTO Published Applications
  • 20160082042 - Use of mesenchymal stem cell-educated macrophages to treat and prevent graft versus host disease and radiation-induced injury, published March 2016.
Recent Publication(s)
  • Human mesenchymal stem cell-educated macrophages are a distinct high IL-6 producing subset that confer protection in graft-versus-host-disease and radiation injury models. Bouchlaka MN, Moffitt AB, Kim J, Kink JA, Bloom DD, Love C, Dave S, Hematti P, Capitini CM. Biol Blood Marrow Transplant. 2017 Feb 28. pii: S1083-8791(17)30306-3. doi: 10.1016/j.bbmt.2017.02.018. [Epub ahead of print]

  • Successful matched unrelated donor stem cell transplant in hemoglobin bart's disease. Elsaid MY, Capitini CM, Diamond CA, Porte M, Otto M, DeSantes KB. Bone Marrow Transplant. 2016 Nov;51(11):1522-1523. doi: 10.1038/bmt.2016.153. No abstract available.

  • Fbxo10 deficiency and btk activation upregulate bcl2 expression in mantle cell lymphoma. Li Y, Bouchlaka MN, Wolff J, Grindle KM, Lu L, Qian S, Zhong X, Pflum N, Jobin P, Kahl BS, Eickhoff JC, Wuerzberger-Davis SM, Miyamoto S, Thomas CJ, Yang DT, Capitini CM, Rui L. Oncogene. 2016 Dec 1;35(48):6223-6234. doi: 10.1038/onc.2016.155.

  • (19)F-MRI for monitoring human NK cells in vivo. Bouchlaka MN, Ludwig KD, Gordon JW, Kutz MP, Bednarz BP, Fain SB, Capitini CM. Oncoimmunology. 2016 Feb 18;5(5):e1143996. doi: 10.1080/2162402X.2016.1143996.
Recent Artistic Works
Collaboration
  • National Cancer Institute, Center for Cancer Research, Pediatric Oncology Branch
  • National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Laboratory of Genetics and Physiology
  • American Family Children's Hospital
  • Meriter Hospital
  • St. Mary's Hospital
Research Tools
Research Facilities
E-mail Address [email protected]
Phone Number 608-262-2415
Current University UW–Madison
Department Pediatrics
Title Assistant Professor
Other Appointments
Address Line 1 Wisconsin Institutes for Medical Research
Address Line 2 1111 Highland Avenue
City Madison
State WI
Zip Code 53705
Bachelor's Degree B.A., Drew University, Biology, 1998
Master's Degree
PhD
Other Degrees M.D., University of Rochester School of Medicine and Dentistry, 2002
Technologies Available for Licensing