Wisconsin Discovery Portal

Researcher: John Svaren

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Areas of Expertise
  • Mechanisms of transcriptional control
  • Peripheral nerve diseases
  • EGR2 mutations
  • Gene microarrays
  • Quantitative PCR assays
  • EGR2 and NAB proteins 
  • Myelination of peripheral nerves by Schwann cells
  • Dynamic regulation of Schwann cell
  • Peripheral nerve myelin maintenance
  • Early life stress and gene methylation in children
Web Site John Svaren's Waisman Center Website
Curriculum Vitae (CV)
Issued Patent(s)
USPTO Published Applications
  • 20140080787 - Method for the treatment of neuropathies associated with charcot-marie-tooth 1a (CMT1A) disease, published March 2014.
Recent Publication(s)
  • Tead1 regulates the expression of peripheral myelin protein 22 during schwann cell development. Lopez-Anido C, Poitelon Y, Gopinath C, Moran JJ, Ma KH, Law WD, Antonellis A, Feltri ML, Svaren J. Hum Mol Genet. 2016 Jun 10. pii: ddw158. [Epub ahead of print]

  • Yap and taz control peripheral myelination and the expression of laminin receptors in schwann cells. Poitelon Y, Lopez-Anido C, Catignas K, Berti C, Palmisano M, Williamson C, Ameroso D, Abiko K, Hwang Y, Gregorieff A, Wrana JL, Asmani M, Zhao R, Sim FJ, Wrabetz L, Svaren J, Feltri ML. Nat Neurosci. 2016 Jul;19(7):879-87. doi: 10.1038/nn.4316. Epub 2016 Jun 6.

  • Regulation of peripheral nerve myelin maintenance by gene repression through polycomb repressive complex 2. Ma KH, Hung HA, Srinivasan R, Xie H, Orkin SH, Svaren J. J Neurosci. 2015 Jun 3;35(22):8640-52. doi: 10.1523/JNEUROSCI.2257-14.2015.

  • Differential sox10 genomic occupancy in myelinating glia. Lopez-Anido C, Sun G, Koenning M, Srinivasan R, Hung HA, Emery B, Keles S, Svaren J. Glia. 2015 May 14. doi: 10.1002/glia.22855. [Epub ahead of print]
Recent Artistic Works
Collaboration
  • Intra-University Collaboration: Neurology, School of Veterinary Medicine, Molecular and Cellular Pharmacology Program, Biochemistry
  • National Institute for Medical Research (England), Molecular Immunology
Research Tools
Research Facilities Svaren Lab
E-mail Address [email protected]
Phone Number 608-263-4246
Current University UW–Madison
Department Comparative Biosciences
Title Professor
Other Appointments
Address Line 1 661 Waisman Center
Address Line 2 1500 Highland Avenue
City Madison
State WI
Zip Code 53705
Bachelor's Degree B.A., Augustana College, Biology, 1985
Master's Degree
PhD Ph.D., Vanderbilt University, Molecular Physiology and Biophysics, 1992
Other Degrees
Technologies Available for Licensing