Wisconsin Discovery Portal

Researcher: Christian Capitini

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Areas of Research Expertise

* Pediatric hematology
* Pediatric oncology
* Donor Lymphocyte Infusion (DLI)
* Allogeneic blood and marrow transplant (alloBMT)

Web Site Christian Capitini's UW Health Page
Curriculum Vitae (CV)
Current/Active Funding
  • Hyundai Motor America, 2011-2012, Development of STAT1 inhibitors for treating pediatric leukemia and modulation of allogeneic bone marrow transplant
Issued Patent(s)  
USPTO Published Applications
 
Recent Publication(s)
  • "Extracorporeal photopheresis attenuates murine graft-versus-host disease via bone marrow-derived interleukin-10 and preserves responses to dendritic cell vaccination"

Capitini CM, Davis JP, Larabee SM, et al., Biol Blood Marrow Transplant 17 (6): 790-799 Jun 2011. We demonstrate that ECP-treated splenocytes attenuate GVHD irrespective of the source of ECP-treated cells via a mechanism that likely involves modulation of DCs and requires IL-10 produced by BM-derived cells. Importantly, the attenuation of GVHD by ECP-treated splenocytes permits donor lymphocyte infusion-dependent responses to DC vaccines after allo-BMT. Pubmed.

  • "Identification and characterization of two Bordetella avium gene products required for hemagglutination"

Temple LM, Miyamoto DM, Mehta M, et al., Infect Immun 78 (6): 2370-2376 Jun 2010. We report the use of transposon mutagenesis to identify two genes required for hemagglutination. The genes (hagA and hagB) were adjacent and divergently oriented and had no orthologs in the genomes of other Bordetella species. Pubmed.

  • "Immunotherapy of childhood cancer: from biologic understanding to clinical application"

Wayne AS, Capitini CM, Mackall CL, Curr Opin Pediatr 22 (1): 2-11 Feb 2010. Recent clinical trial results provide proof-of-principle that cancer immunotherapy has the capacity to overcome chemotherapy resistance without the usual toxicities associated with cytotoxic regimens. Immunotherapy holds promise in the treatment of children and adolescents with cancer and has the potential to improve both survival and quality of life. Pubmed.

  • "Immune-based therapeutics for pediatric cancer"

Capitini CM, Mackall CL, Wayne AS, Expert Opin Biol Ther 10 (2): 163-178 Feb 2010. Some immune-based therapies, such as ch14.18 and MTP-PE, have already been proven effective in phase III randomized trials. Further studies are needed to optimize and integrate other therapies into standard regimens, and to test them in randomized trials for patients with childhood cancer. Pubmed.

Recent Artistic Works  
Collaboration
  • American Family Children's Hospital
  • Meriter Hospital
  • St. Mary's Hospital
Research Tools  
Research Facilities  
E-mail Address [email protected]
Phone Number (608) 262-2415
Current University UW-Madison
Department Pediatrics
Title Assistant Professor
Other Appointments  
Address Line 1 4137 WIMR
Address Line 2 1111 Highland Ave
City Madison
State WI
Zip Code 53705
Bachelor's Degree BA, Drew University, Biology, 1998
Master's Degree
PhD
Other Degrees MD, University of Rochester School of Medicine and Dentistry, 2002
Technologies Available for Licensing