|Areas of Research Expertise||
* Pediatric hematology
|Web Site||Christian Capitini's UW Health Page|
|Curriculum Vitae (CV)|
|USPTO Published Applications|
Capitini CM, Davis JP, Larabee SM, et al., Biol Blood Marrow Transplant 17 (6): 790-799 Jun 2011. We demonstrate that ECP-treated splenocytes attenuate GVHD irrespective of the source of ECP-treated cells via a mechanism that likely involves modulation of DCs and requires IL-10 produced by BM-derived cells. Importantly, the attenuation of GVHD by ECP-treated splenocytes permits donor lymphocyte infusion-dependent responses to DC vaccines after allo-BMT. Pubmed.
Temple LM, Miyamoto DM, Mehta M, et al., Infect Immun 78 (6): 2370-2376 Jun 2010. We report the use of transposon mutagenesis to identify two genes required for hemagglutination. The genes (hagA and hagB) were adjacent and divergently oriented and had no orthologs in the genomes of other Bordetella species. Pubmed.
Wayne AS, Capitini CM, Mackall CL, Curr Opin Pediatr 22 (1): 2-11 Feb 2010. Recent clinical trial results provide proof-of-principle that cancer immunotherapy has the capacity to overcome chemotherapy resistance without the usual toxicities associated with cytotoxic regimens. Immunotherapy holds promise in the treatment of children and adolescents with cancer and has the potential to improve both survival and quality of life. Pubmed.
Capitini CM, Mackall CL, Wayne AS, Expert Opin Biol Ther 10 (2): 163-178 Feb 2010. Some immune-based therapies, such as ch14.18 and MTP-PE, have already been proven effective in phase III randomized trials. Further studies are needed to optimize and integrate other therapies into standard regimens, and to test them in randomized trials for patients with childhood cancer. Pubmed.
|Recent Artistic Works|
|E-mail Address||[email protected]|
|Phone Number||(608) 262-2415|
|Address Line 1||4137 WIMR|
|Address Line 2||1111 Highland Ave|
|Bachelor's Degree||BA, Drew University, Biology, 1998|
|Other Degrees||MD, University of Rochester School of Medicine and Dentistry, 2002|
|Technologies Available for Licensing|