Wisconsin Discovery Portal

Researcher: Jean-Michel Ane

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Areas of Research Expertise
* Development of symbiotic associations between plants and microbes using the model legume Medicago truncatula
* Unravel the molecular process involved in plant-microbe symbiotic associations: legume nodulation and arbuscular mycorrhization
* Focuses on plant genes regulating the establishment of these symbioses to understand how symbiotic signals are received and transduced by host plants
* Transfers information from the model legume M. truncatula to legume crops like alfalfa and soybeans
* Develops genetic tools to analyze arbuscular mycorrhiza in monocots (maize, wheat...) and primitive plants (mosses and ferns)
Web Site Jean-Michel Ane's University Web Page
Curriculum Vitae (CV) Jean-Michel Ane's CV
Current/Active Funding
  • NSF, 2010-2013, Role of a 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase in plant-microbe symbiotic signaling pathways
  • NSF, 2012-2015, An Interdisciplinary Approach To Deciphering The Molecular Dialogue Between The Plasma Membrane And Cytoplasm Of Medicago Truncatula
Issued Patent(s)
  • 7,205,450 - DMI1 gene encodes a protein that is required for the early steps of bacterial and fungal symbioses, granted Apr 2007.
USPTO Published Applications
 
Recent Publication(s)
  • "Evolution of the plant-microbe symbiotic 'toolkit'"

Delaux PM, Sejalon-Delmas N, Becard G, et al., Trends in Plant Science: Feb 2013. Beneficial associations between plants and arbuscular mycorrhizal fungi play a major role in terrestrial environments and in the sustainability of agroecosystems. Proteins, microRNAs, and small molecules have been identified in model angiosperms as required for the establishment of arbuscular mycorrhizal associations and define a symbiotic 'toolkit' used for other interactions such as the rhizobia-legume symbiosis. Based on recent studies, researchers propose an evolutionary framework for this toolkit.  Pubmed/NLM.

  • "Symbiosis and the social network of higher plants"

Venkateshwaran M, Volkening JD, Sussman MR, et al., Current Opinion in Plant Biology 16 (1): 118-27 Feb 2013.  In general, recent advances in the understanding of such molecular machinery required for plant-symbiont associations are being obtained using high throughput genomic profiling strategies including transcriptomics, proteomics and metabolomics. The crucial mechanistic understanding that such data reveal may provide the infrastructure for future efforts to genetically manipulate crop social networks for our own food and fiber needs.  Pubmed/NLM.

  • "Metabolomic profiling reveals suppression of oxylipin biosynthesis during the early stages of legume-rhizobia symbiosis"

Zhang N, Venkateshwaran M, Boersma M, et al., FEBS Letters 586 (19): 3150-8 Sep 2012.  Researchers utilized untargeted quantitative mass spectrometry to perform metabolomic profiling of small molecules in extracts of the model legume Medicago truncatula treated with rhizobial Nod factors.  Pubmed/NLM.

  • "A proteogenomic survey of the Medicago truncatula genome"

Volkening JD, Bailey DJ, Rose CM, et al., Molecular & Cellular Proteomics 11 (10): 933-44 Oct 2012.  Researchers report herein the application of proteogenomic methodology to a database of 10.9 million tandem mass spectra collected over a period of two years from proteolytically generated peptides isolated from the model legume Medicago truncatula.  Pubmed/NLM.

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E-mail Address [email protected]
Phone Number (608) 262-6457
Current University UW - Madison
Department Agronomy
Title Associate Professor
Other Appointments  
Address Line 1 348 Moore Hall
Address Line 2 1575 Linden Drive
City Madison
State WI
Zip Code 53706
Bachelor's Degree BS, University of Lyon, Molecular and Cellular Biology, 1995
Master's Degree MS, University of Toulouse, Plant Cellular and Molecular Biology, 1997
PhD PhD, University of Toulouse, Plant Cellular and Molecular Biology, 2002
Other Degrees
Technologies Available for Licensing