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Researcher's Profile

Last Name

Kwon

First Name

Glen

Middle Initial

Areas of Research Expertise

* Drug delivery

* Polymeric nanobiomaterials

* Antigen delivery

* Non-viral gene delivery

Web site

Glen Kwon's University Web Page

Curriculum Vitae (CV)

Current/Active Funding

Wisconsin Alumni Research Foundation, 2011-2012, Polymeric Micelles For Multiple Drug Delivery
NIH, 2007-2012, Artificial Polymeric Lipoproteins as Drug Carriers
DHHS, NIH, 2011-2013, Tri-modal Polymeric Micelles for 'See & Treat' Applications in Surgical Oncology

Issued Patent(s)

7,416,870 - Methods of directing C-O bond formation utilizing a type II polyketide synthase system, granted Apr 2008.
6,939,561 - Methods and compositions for polyene antibiotics with reduced toxicity, granted Sep 2005.
6,413,537 - Nystatin formulation having reduced toxicity, granted Jul 2002.
6,168,804 - Method for eliciting Th1-specific immune response, granted Jan 2001.

USPTO Published Applications

20110076682 - Over-production of secondary metabolites by over-expression of the VeA gene, Mar 2011.
20090036389 - Polymeric micelle formulations of hydrophobic compounds and methods, published Feb 2009.
20080194500 - Semi-fluorinated block copolymers for delivery of therapeutic agents, published Aug 2008.
20080038353 - Polymer Based Nano-Carriers For The Solubilization And Delivery Of Hydrophobic Drugs, published Feb 2008.
20060251710 - Micelle composiiton of polymer and passenger drug, published Nov 2006.

Recent Publication(s)

"A 3-in-1 Polymeric Micelle Nanocontainer for Poorly Water-Soluble Drugs"

Shin HC, Alani AWG, Cho H, et al., Molecular Pharmaceutics 8(4): 1257-1265 Jul 2011. We show that PEG-b-PLA micelles act as a 3-in-1 nanocontainer for paclitaxel, 17-allylamino-17-demethoxygeldanamycin (17-AAG), and rapamycin for multiple drug solubilization.

"Resveratrol Metabolites Do Not Elicit Early Pro-apoptotic Mechanisms in Neuroblastoma Cells"

Kenealey JD, Subramanian L, Van Ginke PR et al., Journal of Agricultural and Food Chemistry 59 (9): 4979-4986 May 2011. This study demonstrates that resveratrol alone, and not the glucuronidated or sulfated metabolites, is taken up into tumor cells, induces a rise in [Ca2+](i), and ultimately leads to a decrease in tumor cell viability.

"Pharmacokinetics and Nephrotoxicity of Amphotericin B-Incorporated Poly(Ethylene Glycol)-Block-Poly(N-Hexyl Stearate l-aspartamide) Micelles"

Diezi TA, Davies NM, Kwon GS, et al., Journal of Pharmaceutical Sciences 100(6): 2064-2070 June 2011. The purpose of this investigation was to study the pharmacokinetics and nephrotoxicity of amphotericin B (AmB), incorporated in poly(ethylene glycol)-block-poly(N-hexyl stearate l-aspartamide) (PEG-b-PHSA) micelles (AmB/PEG-b-PHSA).

"Mixed pH-Sensitive Polymeric Micelles for Combination Drug Delivery"

Bae Y, Alani AWG, Rockich NC, et al., Pharmaceutical Research 27 (11): 2421-2432 Nov 2010. Study prepared mixed polymeric micelles that can carry two different drugs, doxorubicin (DOX) and 17-hydroxyethylamino-17-demethoxygeldanamycin (GDM-OH), for combination cancer chemotherapy.