Shin HC, Alani AWG, Cho H, et al., Molecular Pharmaceutics 8(4): 1257-1265 Jul 2011. We show that PEG-b-PLA micelles act as a 3-in-1 nanocontainer for paclitaxel, 17-allylamino-17-demethoxygeldanamycin (17-AAG), and rapamycin for multiple drug solubilization.
Kenealey JD, Subramanian L, Van Ginke PR et al., Journal of Agricultural and Food Chemistry 59 (9): 4979-4986 May 2011. This study demonstrates that resveratrol alone, and not the glucuronidated or sulfated metabolites, is taken up into tumor cells, induces a rise in [Ca2+](i), and ultimately leads to a decrease in tumor cell viability.
Diezi TA, Davies NM, Kwon GS, et al., Journal of Pharmaceutical Sciences 100(6): 2064-2070 June 2011. The purpose of this investigation was to study the pharmacokinetics and nephrotoxicity of amphotericin B (AmB), incorporated in poly(ethylene glycol)-block-poly(N-hexyl stearate l-aspartamide) (PEG-b-PHSA) micelles (AmB/PEG-b-PHSA).
Bae Y, Alani AWG, Rockich NC, et al., Pharmaceutical Research 27 (11): 2421-2432 Nov 2010. Study prepared mixed polymeric micelles that can carry two different drugs, doxorubicin (DOX) and 17-hydroxyethylamino-17-demethoxygeldanamycin (GDM-OH), for combination cancer chemotherapy.