• NIH, 2006-2011, Pandemic Potential of H5N1 Influenza Viruses
• Gates Foundation, 2007-2010, High-throughput systems to generate and screen influenza viral protection libraries for biologically functional proteins
• Multiple Funding Sources in Influenza and Ebola Virus Studies

• 7,723,094 - Recombinant influenza vectors with a Pol II promoter and ribozymes for vaccines and gene therapy, granted May 2010. 
• 7,226,774 - Signal for packaging of influenza virus vectors, granted Jun 2007.
• 7,211,378 - Filovirus vectors and noninfectious filovirus-based particles, granted May 2007.
• 7,176,021 - Mutant cells with altered sialic acid, granted Feb 2007.
• 6,872,395 - Viruses comprising mutant ion channel protein, granted Mar 2005.

• "Cellular networks involved in the influenza virus life cycle"

Watanabe T, Watanabe S, Kawaoka Y, Cell Host and Microbe 7(6): 427-439 June 2010.  In this review, the authors examine cellular genes identified to date as important for influenza virus replication in genome-wide screens, assess pathways that were repeatedly identified in these studies, and discuss how these pathways might be involved in the individual steps of influenza virus replication, ultimately leading to a comprehensive understanding of the virus life cycle. 

• "Minigenome-Based Reporter System Suitable for High-Throughput Screening of Compounds Able To Inhibit Ebolavirus Replication and/or Transcription"

Jasenosky LD, Neumann G, Kawaoka Y, Antimicrobial Agents and Chemotherapy 54 (7): 3007-3010 Jul 2010.  We describe an Ebolavirus minigenome-based system that is suitable for high-throughput screening of compounds able to impair Ebolavirus virus replication and/or transcription. The assay is robust (Z' factor, >0.6) and can be carried out in low-biosafety containment. Results from a pilot screen of 960 compounds are presented.

• "Role of host-specific amino acids in the pathogenicity of avian H5N1 influenza viruses in mice"

Kim JH, Hatta M, Watanabe S, Neumann G, Watanabe T, Kawaoka Y, Journal of General Virology 91: 1284-1289 May 2010.  The authors found that mutants exhibited enhanced pathogenicity in mice, suggesting the involvement of these host lineage-specific amino acids in the pathogenicity of H5N1 avian influenza viruses in mammals. 

• "A role for the C terminus of Mopeia virus nucleoprotein in its incorporation into Z protein-induced virus-like particles"

Shtanko O, Imai M, Goto H, Lukashevich IS, Neumann G, et al., Journal of Virology 84(10): 5415-5422 May 2010.  The Z protein promoted the association of NP with cellular membranes, suggesting that the association of NP, Z, and the cellular membranes may facilitate the efficient incorporation of NP into VLPs. 

• "Role of GTPase Rab1b in Ebolavirus Particle Formation"

Yamayoshi S, Neumann G, Kawaoka Y, Journal of Virology 84(9): 4816-4820 May 2010.  The authors demonstrate that GBF1 and ARF1 are involved in Ebolavirus virion formation, suggesting that both the COPII and COPI transport systems play a role in Ebolavirus VP40-mediated particle formation.

• University of Tokyo, International Research Center of Infectious Diseases, Department of Special Pathogens, Microbiology & Immunology, Virology
• University of Pittsburgh
• University of Manitoba, National Microbiology Lab, Public Health Agency of Canada, Special Pathogens Program, Medical Microbiology
• Japan Science & Technology Agency, ERATO, Infectious Induced Host Responses Project
• Kobe University, International Center of Medical Research & Treatment
• Airlangga University, Veterinary Medicine, Collaborating Research Center