- "A Drosophila behavioral mutant, down and out (dao), is defective in an essential regulator of Erg potassium channels"
Fergestad T, Sale H, Bostwick B, et al., Proceedings of the National Academy of Sciences of the United States of America 107 (12): 5617-5621 Mar 2010. Dao has an important role in establishing the proper level of neuronal membrane excitability by regulating functional expression of Erg channels. PubMed/NLM.
- "Endocytic control of ion channel density as a target for cardiovascular disease"
Robertson GA, J Clin Invest 119 (9): 2531-2534 Sep 2009. The authors identified mutations in TRPM4--a nonselective cation channel--in a large family with progressive familial heart block type I and showed that these mutations prevented channel internalization. Pubmed/NLM.
- "hERG gating microdomains defined by S6 mutagenesis and molecular modeling"
Wynia-Smith SL, Gillian-Daniel AL, Satyshur KA, Journal of General Physiology 132 (5): 507-520 Nov 2008. We introduced cysteine mutations into the hERG channel S6 domain and measured mutational effects on the steady-state distribution and kinetics of transitions between the closed and open states.
- "Physiological properties of hERG 1a/1b heteromeric currents and a hERG 1b-specific mutation associated with Long-QT syndrome"
Sale H, Wang J, O'Hara TJ, et al., Circ Res 103 (7): e81-95 Sep 2008. Here, we examine currents produced by hERG 1a and 1a/1b channels expressed in HEK-293 cells at near-physiological temperatures. We find that heteromeric hERG 1a/1b currents are much larger than hERG 1a currents and conduct 80% more charge during an action potential.