Wisconsin Discovery Portal

Researcher's Profile

Last Name

Chen 

First Name

Herbert 

Middle Initial

 

Areas of Research Expertise

* Development, progression, and treatment of endocrine tumors including gastrointestinal carcinoids, thyroid cancer, adrenal cancer, and pancreatic islet cell tumors
*  The role of cellular signaling pathways in the differentiation and growth of neuroendocrine (NE) tumors including carcinoid, pancreatic islet cell, pheochromocytoma, and medullary thyroid cancer

Web site

Dr. Herbert Chen's University Website 

Curriculum Vitae (CV)

 

Current/Active Funding

  • Doctors Cancer Foundation, Inc, 2006-2099, The Role of GSK3B in Carcinoid and other Neuroendocrine Cancers 
  • University of Wisconsin-Madison, 2007-2034, Valproic Acid - Thyroid Cancer
  • NIH, 2009-2014, GSK3-Beta Signaling in Medullary Thyroid Cancer
  • NIH, 2011-2013, Surgery Summer Research Experience for Medical Students
  • American Cancer Society, Inc, 2010-2015, Establishment of an MEN2 Thyroid Cancer Research and Training Program
  • Saudi Arabian Cultural Mission, 2009-2014, Memorandum of Understanding between the Saudi Cultural Mission and the Board of the University of Wisconsin Systems to Establish a Surgical Fellowship
  • NIH, 2011-2016, Surgical Oncology Research Training Program
  • NIH, 2011-2013, AAS Courses to Increase Women and Minorities in Academic Surgery
  • American College of Surgeons, 2011-2013, Targeting Notch in Medullary Thyroid Cancer Fellowship for Jocelyn Burke
  • American Cancer Society, Inc, 2011-2016, Notch Signaling in Medullary Thyroid Cancer
  • Novo Nordisk Pharmaceuticals, Inc, 2011-2026, Medullary Thyroid Carcinoma Surveillance Study: a Case Series Registry
  • UWF- University of Wisconsin Foundation, 2012-2014, Surgery Clinical Research Experiences for High School Students

Issued Patent(s)

  • 8,338,482 - Modulating notch1 signaling pathway for treating neuroendocrine tumors, granted Dec 2012.

USPTO Published Applications

  • 20080045445 - Modulating notchl signaling pathway for treating neuroendocrine tumors, granted Feb 2008.
  • 20060121040 - Compositions and methods for treating neuroendocrine tumors, granted Jun 2006.
  • 20060025485 - Hydroxybenazamide compounds for treatment of cancer, granted Feb 2006. 

Recent Publication(s)

  • "REMNANT UPTAKE AS A POSTOPERATIVE ONCOLOGIC QUALITY INDICATOR"

Schneider DF, Ojomo KA, Chen H, et al., Thyroid: official journal of the American Thyroid Association Feb 2013. The purpose of this study was to examine the utility of remnant uptake on postoperative radioiodine scans as an oncologic indicator after thyroidectomy for differentiated thyroid cancer (DTC). Pubmed/NLM.

  • ""Early-phase technetium-99m sestamibi scintigraphy can improve preoperative localization in primary hyperparathyroidism"

Burke JF, Naraharisetty K, Schneider DF, et al., American Journal of Surgery Jan 2013. A review of early scans in patients with negative imaging increases accurate adenoma localization and allows for minimally invasive operations in more patients. Pubmed/NLM.

  • "Lymph Node Ratio Predicts Recurrence in Papillary Thyroid Cancer"

Schneider DF, Mazeh H, Chen H, et al., The Oncologist Jan 2013. Lymph node metastasis occurs in 20%-50% of patients presenting for initial treatment of papillary thyroid cancer (PTC). The significance of lymph node metastases remains controversial, and the aim of this study is to determine how the lymph node ratio (LNR) may predict the likelihood of disease recurrence. Pubmed/NLM.

  • "Using Body Mass Index to Predict Optimal Thyroid Dosing after Thyroidectomy"

Ojomo KA, Schneider DF, Reiher AE, et al., Journal of the American  College of Surgeons Jan 2013. The current standard of weight-based thyroid replacement fails to appropriately dose underweight and overweight patients. Body mass index can be used to more accurately dose thyroid hormone using a simple formula. Pubmed/NLM.

Recent Artistic Works

 

Collaboration

 

Research Tools

 

Research Facilities

 

E-mail Address

chen@surgery.wisc.edu 

Phone Number

(608) 263-1387 

Current University

UW - Madison 

Department

Surgery 

Title

Professor 

Other Appointments

Chairman, Division of General Surgery
Vice-Chairman of Research, Department of Surgery

Address Line 1

Box 7375 Clinical Sciences Center 

Address Line 2

600 Highland Avenue 

City

Madison 

State

WI 

Zip Code

53792 

Bachelor's Degree

 

Master's Degree

 

PhD

 

Other Degrees

MD, Duke University School of Medicine, 1992

Technologies Available for Licensing

Attachments
Created at 7/17/2007 1:33 PM  by EXTWEB\egulbrandsen 
Last modified at 2/6/2013 12:38 PM  by EXTWEB\mevans