Last Name |
Blattner
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First Name |
Frederick
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Middle Initial |
R
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Areas of Research Expertise |
* Genomics
* Gene Regulation
* Bacteria
* Bioinformatics
* DNAchips
* Genome engineering
* Large scale fuctional genomics of E. coli through DNA chip analysis of global gene expression and by phenotypic analysis of conditional knock-out mutations
* Studies E. coli K1, a cause of neonatal sepsis and meningitis
* Plans to sequence Yersinia Pestis (plague), Shigella flexneri (dysentary), and Salmonella typhi (typhoid fever)
* Seeks to identify a "pathosphere" of the virulence of genes that make up the pathogenic potential of these bacteria |
Web site |
Frederick Blattner's University Web Page
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Curriculum Vitae (CV) |
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Current/Active Funding |
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Issued Patent(s) |
- 8,178,339 - Reduced genome E. coli, granted May 2012.
- 8,119,365 - Insertion sequence-free bacteria, granted Feb 2012.
- 8,043,842 - Bacteria with reduced genome, granted Oct 2011.
- 8,039,243 - Insertion sequence-free bacteria, granted Oct 2011.
- 8,030,477 - Methods for the synthesis of arrays of DNA probes, granted Oct 2011.
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USPTO Published Applications |
- 20130011874 - Reduced Genome E. coli, granted Jan 2013.
- 20120219994 - Prophage Element-Free Bacteria, granted Aug 2012.
- 20120093865 - Compositions Comprising Reduced Genome Bacteria for Use in Treatment of Sepsis, granted Apr 2012.
- 20110293662 - Compositions Comprising Reduced Genome Bacteria for Use in Treatment of Sepsis, granted Dec 2011.
- 20110165680 - Clean Genome Bactofection, granted July 2011.
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Recent Publication(s) |
- "Genome sequence of the plant-pathogenic bacterium Dickeya dadantii 3937"
Glasner JD, Yang CH, Reverchon S, et al., Journal of Bacteriology 193 (8): 2076-2077 Apr 2011. DNA, Bacterial/chemistry; DNA, Bacterial/genetics; Enterobacteriaceae/genetics; Enterobacteriaceae/isolation & purification; Genome, Bacterial; Molecular Sequence Data; Plant Diseases/microbiology; Plants/microbiology; Sequence Analysis, DNA. Pubmed/NLM.
- "Research reduced evolvability of Escherichia coli MDS42, an IS-less cellular chassis for molecular and synthetic biology applications"
Umenhoffer K, Feher T, Baliko G, et al., Microbial Cell Factories 9(38): May 2010. Bioinformatics analysis of sequence reads from early shotgun genome sequencing projects suggests that such IS-mediated inactivation of ectopic genes inhibiting the growth of the E. coli cloning host might happen more frequently than generally anticipated, leading to genomic instability and selection of altered clones.
- "Delivery of biologically active recombinant interleukin 10 in Escherichia coli using different modified bacterial transport systems"
Pohlmann C, Brandt M, Schmidt DS, et al., International Journal of Medical Microbiology 299 (Suppl. 46): 93-93 Sep 2009. Meeting abstract.
- "The complete genome sequence of Escherichia coli DH10B: Insights into the biology of a laboratory workhorse"
Durfee, T; Nelson, R; Baldwin, S, et al., Journal of Bacteriology 190 (7): 2597-2606, Apr 2008. IS elements appear to have remodeled genome architecture, providing homologous recombination sites for a 113,260-bp tandem duplication and an inversion. DH10B requires leucine for growth on minimal medium due to the deletion of leuLABCD and harbors both the reLA1 and spoT1 alleles causing both sensitivity to nutritional downshifts and slightly lower growth rates relative to the wild type. Finally, while the sequence confirms most of the reported alleles, the sequence of deoR is wild type, necessitating reexamination of the assumed basis for the high transformability of DH10B. |
Recent Artistic Works |
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Collaboration |
- University of California-San Diego: Bioengineering, Bioinformatics, Chemistry, Biochemistry
- CUNY, Division of Infectious Diseases
- Nimblegen System Inc
- Clemson University: Bioengineering, Chemical & Biomolecular Engineering
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Research Tools |
- Sequenced bacterial strains available: E. coli K-12 MG1655
- ASAP database, a relational database and web interface developed to store, update, and distribute genome sequences in conjunction with associated annotations and functional characterization data.
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Research Facilities |
- Genetics Sequencing & Genomics Services Center
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E-mail Address |
fred@genome.wisc.edu
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Phone Number |
(608) 890-0191
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Current University |
UW - Madison
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Department |
Genetics
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Title |
Professor Emeritus
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Other Appointments |
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Address Line 1 |
1420 Genetics-Biotechnology Building
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Address Line 2 |
425 Henry Mall
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City |
Madison
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State |
WI
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Zip Code |
53706
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Bachelor's Degree |
BSc, Oberlin College, Physics, 1962
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Master's Degree |
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PhD |
PhD, Johns Hopkins University, Biophysics, 1968
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Other Degrees |
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Technologies Available for Licensing |
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Attachments
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