• NIH, 2006-2011, Mechanisms of an Aspergillus Fumigatus Virulence Mutant
• Wisconsin Alumni Research Foundation, 2007-2012, Kellett Mid-Career Faculty Researcher

• 7,427,484 - Global regulator of secondary metabolite biosynthesis and methods of use, granted Sep 2008.
• 7,053,204 - Global regulator of secondary metabolite biosynthesis and methods of use, granted May 2006.
• 6,627,797 - Maize lipoxygenase polynucleotide and methods of use, granted Sep 2003.

• "Unraveling polyketide synthesis in members of the genus Aspergillus"

Chiang YM, Oakley BR, Keller NP, Wang CCC, Applied Microbiology and Biotechnology 86(6): 1719-1736 May 2010.  The authors highlight current knowledge regarding polyketide biosynthesis in Aspergillus based on the domain architecture of non-reducing, highly reducing, and partially reducing PKSs and PKS-non-ribosomal peptide synthetases. 

• "Involvement of transposon-like elements in penicillin gene cluster regulation"

Shaaban M, Palmer JM, El-Naggar WA, El-Sokkary MA, Habib EE, Keller NP, Fungal Genetics and Biology 47(5): 423-432 May 2010.  Trans-complementation of the Pbla element near and within the terrequinone A cluster on chromosome V did not restore penicillin biosynthesis or increase production of terrequinone A. 

• "Characterization of the aspergillus nidulans monodictyphenone gene cluster"

Chiang YM, Szewczyk E, Davidson AD, Applied and Enviormental Microbiology 76 (7): 2067-2074 Apr 2010. We propose a biosynthetic pathway for monodictyphenone and emodin derivatives based on bioinformatic analysis and characterization of biosynthetic intermediates.

• "Beyond aflatoxin: four distinct expression patterns and functional roles associated with Aspergillus flavus secondary metabolism gene clusters"

Georgianna DR, Fedorova ND, Burroughs JL, Dolezal AL, Bok JW, Molecular Plant Pathology 11(2): 213-226 Mar 2010.  Results from these studies showed that secondary metabolism gene clusters have distinctive gene expression profiles.  Aflatoxin and CPA were found to have unique regulation, but are sufficiently similar that they would be expected to co-occur in substrates colonized with A. flavus.

• "Unlocking fungal cryptic natural products"

Chiang YM, Lee KH, Sanchez JF, et al., Natural Product Communications 4 (11): 1505-1510 Nov 2009. This review describes recent strategies to mine the cryptic natural products and their biosynthetic pathways in fungi.

• "HdaA, a class 2 histone deacetylase of Aspergillus fumigatus, affects germination and secondary metabolite production"

Lee I, Oh JH, Shwab EK, et al., Fungal Genetics and Biology 46 (10): 782-790 Oct 2009. Here the authors show that the Aspergillus fumigatus HDAC HdaA is involved in regulation of secondary metabolite production and is required for normal germination and vegetative growth.  

• Tech University of Denmark
• University of Washington
• University of Frieburg, Germany
• John Innes Center for Plant Science Research
• Food Research Institute