Last Name |
Clagett-Dame
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First Name |
Margaret
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Middle Initial |
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Areas of Research Expertise |
* Molecular mechanism of action of vitamin A in embryonic development
* Vitamin A and neuronal survival and differentiation
* Retinoids in chemoprevention and chemotherapy
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Web site |
Margaret Clagett-Dame's University Web Page
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Curriculum Vitae (CV) |
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Current/Active Funding |
- American Association of Colleges of Pharmacy, 1989-2017, The Influence of Retinoic Acid on Neural Tissues: Use of Human Neuroblastoma Cells as a Model System
- Wisconsin Alumni Research Foundation, 2010-2035, WARF Accelerator Program - "In-vivo Research with the Compound 4HBR
- Deltanoid Pharmaceuticals, Inc., 2003-2012, Vitamin A Analog Studies
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Issued Patent(s) |
- 7,947,666 - 2-methylene-(20S,25S)-19,26-dinor-vitamin D analogs, granted May 2011.
- 7,943,601 - 2-methylene-20-methyl-19,24,25,26,27-pentanor-vitamin D analogs, granted May 2011.
- 7,915,242 - Vitamin D receptor antagonists and their use in treating asthma, granted Mar 2011.
- 7,888,339 - 2-methylene-20(21)-dehydro-19-nor-vitamin D analogs, granted Feb 2011.
- 7,879,829 - 19-nor-vitamin D analogs with 1,2-dihydrofuran ring, granted Feb 2011.
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USPTO Published Applications |
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20110034426 - Method of preventing renal disease and treating symptoms thereof, Feb 2011.
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20110105444 - Once-A-Week Administration of 25-Hydroxy Vitamin D3 to Sustain Elevated Steady-State Pharmacokinetic Blood Concentration, May 2011.
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20110086824 - (20S,22E)-2-Methylene-19-Nor-22-Ene-1Alpha,25Dihydroxyvitamin D3, Apr 2011.
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20110082123 - 6-Methylvitamin D3 Analogs and Their Uses, Apr 2011.
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20110082122 - 19-Nor-Vitamin D Analogs with 1,2 or 3,2-Cyclopentene Ring, Apr 2011.
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20110003892 - All-trans retinoid esters as active pharmaceutical ingredients, oral and topical dosage form compositions thereof, and methods of treating skin conditions thereof, Jan 2011.
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Recent Publication(s) |
- "Nav2 hypomorphic mutant mice are ataxic and exhibit abnormalities in cerebellar development"
McNeill EM, Klockner-Bormann M, Roesler EC et al., Developmental Biology 353 (2): 331-343 May 2011.
- "The Vitamin D Analogue 2MD Increases Bone Herein we show that hypomorphic mutant mice lacking the full-length Nav2 transcript exhibit ataxia and defects in cerebellar development. At embryonic day (E)17.5, the mutant cerebellum is reduced in size and exhibits defects in vermal foliation.Turnover but Not BMD in Postmenopausal Women With Osteopenia: Results of a 1-Year Phase 2 Double-Blind, Placebo-Controlled, Randomized Clinical Trial"
DeLuca HF, Bedale W, Binkley N, et al., Journal of Bone and Mineral Research 26(3): 538-545 Mar 2011. In this randomized, double-blind, placebo-controlled study of osteopenic women, the effect of daily oral treatment with 2MD on bone mineral density (BMD), serum markers of bone turnover, and safety were assessed over 1 year.
- "Vitamin A Deficiency Results in Meiotic Failure and Accumulation of Undifferentiated Spermatogonia in Prepubertal Mouse Testis"
Li H, Baehr W, Clagett-Dame M, et al., Biology of Reproduction 84(2): 336-341. In the present study, we found that vitamin A depletion markedly decreased testicular expression of the all-trans retinoic acid-responsive gene, Stra8, and caused meiotic failure in prepubertal male mice lacking lecithin.
- "Vitamin A Deficiency Results in Meiotic Failure and Accumulation of Undifferentiated Spermatogonia in Prepubertal Mouse Testis"
Li H, Palczewski K, Baehr W et al., Biology of Reproduction 84 (2): 336-341 Feb 2011. In the present study, we found that vitamin A depletion markedly decreased testicular expression of the all-trans retinoic acid-responsive gene, Stra8, and caused meiotic failure in prepubertal male mice lacking lecithin: retinol acyltransferase (Lrat), encoding for the major enzyme in liver responsible for the formation of retinyl esters.
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Recent Artistic Works |
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Collaboration |
- Intra University Collaboration: Chemistry, Biochemistry
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Research Tools |
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Research Facilities |
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E-mail Address |
dame@biochem.wisc.edu
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Phone Number |
(608) 262-3450
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Current University |
UW - Madison
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Department |
Biochemistry
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Title |
Professor
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Other Appointments |
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Address Line 1 |
241E Biochemistry Addition
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Address Line 2 |
433 Babcock Drive
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City |
Madison
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State |
WI
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Zip Code |
53706
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Bachelor's Degree |
BS, Pennsylvania State University
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Master's Degree |
MS, Pennsylvania State University
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PhD |
PhD, University of Wisconsin-Madison
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Other Degrees |
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Technologies Available for Licensing |
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Attachments
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