Wisconsin Discovery Portal

Researcher's Profile

Last Name

Clagett-Dame 

First Name

Margaret 

Middle Initial

 

Areas of Research Expertise

* Molecular mechanism of action of vitamin A in embryonic development
* Vitamin A and neuronal survival and differentiation
* Retinoids in chemoprevention and chemotherapy

Web site

Margaret Clagett-Dame's University Web Page 

Curriculum Vitae (CV)

 

Current/Active Funding

  • American Association of Colleges of Pharmacy, 1989-2017, The Influence of Retinoic Acid on Neural Tissues: Use of Human Neuroblastoma Cells as a Model System
  • Wisconsin Alumni Research Foundation, 2010-2035, WARF Accelerator Program - "In-vivo Research with the Compound 4HBR
  • Deltanoid Pharmaceuticals, Inc., 2003-2012, Vitamin A Analog Studies

Issued Patent(s)

  • 7,947,666 - 2-methylene-(20S,25S)-19,26-dinor-vitamin D analogs, granted May 2011.
  • 7,943,601 - 2-methylene-20-methyl-19,24,25,26,27-pentanor-vitamin D analogs, granted May 2011.
  • 7,915,242 - Vitamin D receptor antagonists and their use in treating asthma, granted Mar 2011.
  • 7,888,339 - 2-methylene-20(21)-dehydro-19-nor-vitamin D analogs, granted Feb 2011. 
  • 7,879,829 - 19-nor-vitamin D analogs with 1,2-dihydrofuran ring, granted Feb 2011.

USPTO Published Applications

  • 20110034426 - Method of preventing renal disease and treating symptoms thereof, Feb 2011.
  • 20110105444 - Once-A-Week Administration of 25-Hydroxy Vitamin D3 to Sustain Elevated Steady-State Pharmacokinetic Blood Concentration, May 2011.
  • 20110086824 - (20S,22E)-2-Methylene-19-Nor-22-Ene-1Alpha,25Dihydroxyvitamin D3, Apr 2011.
  • 20110082123 - 6-Methylvitamin D3 Analogs and Their Uses, Apr 2011.
  • 20110082122 - 19-Nor-Vitamin D Analogs with 1,2 or 3,2-Cyclopentene Ring, Apr 2011.
  • 20110003892 - All-trans retinoid esters as active pharmaceutical ingredients, oral and topical dosage form compositions thereof, and methods of treating skin conditions thereof, Jan 2011.

Recent Publication(s)

  • "Nav2 hypomorphic mutant mice are ataxic and exhibit abnormalities in cerebellar development"

McNeill EM, Klockner-Bormann M, Roesler EC et al., Developmental Biology 353 (2): 331-343 May 2011.

  • "The Vitamin D Analogue 2MD Increases Bone Herein we show that hypomorphic mutant mice lacking the full-length Nav2 transcript exhibit ataxia and defects in cerebellar development. At embryonic day (E)17.5, the mutant cerebellum is reduced in size and exhibits defects in vermal foliation.Turnover but Not BMD in Postmenopausal Women With Osteopenia: Results of a 1-Year Phase 2 Double-Blind, Placebo-Controlled, Randomized Clinical Trial"

DeLuca HF, Bedale W, Binkley N, et al., Journal of Bone and Mineral Research 26(3): 538-545 Mar 2011. In this randomized, double-blind, placebo-controlled study of osteopenic women, the effect of daily oral treatment with 2MD on bone mineral density (BMD), serum markers of bone turnover, and safety were assessed over 1 year.

  • "Vitamin A Deficiency Results in Meiotic Failure and Accumulation of Undifferentiated Spermatogonia in Prepubertal Mouse Testis"

Li H, Baehr W, Clagett-Dame M, et al., Biology of Reproduction 84(2): 336-341. In the present study, we found that vitamin A depletion markedly decreased testicular expression of the all-trans retinoic acid-responsive gene, Stra8, and caused meiotic failure in prepubertal male mice lacking lecithin.

  • "Vitamin A Deficiency Results in Meiotic Failure and Accumulation of Undifferentiated Spermatogonia in Prepubertal Mouse Testis"

Li H, Palczewski K, Baehr W et al., Biology of Reproduction 84 (2): 336-341 Feb 2011. In the present study, we found that vitamin A depletion markedly decreased testicular expression of the all-trans retinoic acid-responsive gene, Stra8, and caused meiotic failure in prepubertal male mice lacking lecithin: retinol acyltransferase (Lrat), encoding for the major enzyme in liver responsible for the formation of retinyl esters.

Recent Artistic Works

 

Collaboration

  • Intra University Collaboration: Chemistry, Biochemistry

Research Tools

 

Research Facilities

 

E-mail Address

dame@biochem.wisc.edu 

Phone Number

(608) 262-3450 

Current University

UW - Madison 

Department

Biochemistry 

Title

Professor 

Other Appointments

 

Address Line 1

241E Biochemistry Addition 

Address Line 2

433 Babcock Drive 

City

Madison 

State

WI 

Zip Code

53706 

Bachelor's Degree

BS, Pennsylvania State University

Master's Degree

MS, Pennsylvania State University

PhD

PhD, University of Wisconsin-Madison

Other Degrees

 

Technologies Available for Licensing

Attachments
Created at 6/12/2007 2:07 PM  by Mindy Dawson 
Last modified at 4/24/2012 5:31 PM  by EXTWEB\rshea