Wisconsin Discovery Portal

Researcher's Profile

Last Name

Forest 

First Name

Katrina 

Middle Initial

Areas of Research Expertise

* Structural biology of pathogenesis
* Structural aspects of microbial disease
* X-ray and crystallography
* Structure and assembly of Type IV pili
* Structure of a critical photoreceptor -Phytochrome
* PiLT protein (nucleotide binding protein)

Web site

Katrina Forest's University Web Page 

Curriculum Vitae (CV)

 

Current/Active Funding

  • NIH, 2008-2012, Structural Microbiology of Type IV Pilus Retraction
  • WARF, 2011-2012, Design and Characterization of a Near Infrared Light-Activated Adenyl Cyclase
  • UWF, 2001-2099, Distinguished Young Scholar in Medical Research

Issued Patent(s)

  • 7,087,370 - Kit for vitrifying specimens, granted Aug 2006.
  • 6,500,608 - Method for vitrification of biological cells, granted Dec 2002.

USPTO Published Applications

  • 20090061444 - Phytochrome-based fluorophores, Mar 2009.

Recent Publication(s)

  • "Crystal Structure of the Pseudomonas aeruginosa Virulence Factor Regulator "

Cordes TJ, Worzalla GA, Ginster AM, et al., Journal of Bacteriology 193(16): 4069-4074 Aug 2011.  Virulence factor regulator (Vfr) enhances Pseudomonas aeruginosa pathogenicity through its role as a global transcriptional regulator.

  • "Structure of the minor pseudopilin XcpW from the Pseudomonas aeruginosa type II secretion system"

Franz LP, Douzi B, Durand E et al., Acta Crystallographica Section D-Biological Ctrystallography 67 124-130 Feb 2011. Here, the structure of XcpW(J) was refined to 1.85 A resolution. The structure revealed the type IVa pilin fold with an embellished variable antiparallel beta-sheet as also found in the XcpW(J) homologue enterotoxigenic Escherichia coli GspJ(W) and the XcpU(H) homologue Vibrio cholerae EpsU(H).

  • "Bacterial phytochromes: More than meets the light"

Auldridge ME, Forest KT, Critical Reviews in Biochemistry and Molecular Biology 46 (1): 67-88 Feb 2011. This review focuses on the structures of bacterial phytochromes and implications for signal transmission. We also discuss the small but growing set of bacterial phytochromes for which a physiological function has been ascertained.

  • "P. aeruginosa PilT Structures with and without Nucleotide Reveal a Dynamic Type IV Pilus Retraction Motor"

Misic AM, Satyshur KA, Forest KT, Journal of Molecular Biology 400 (5): 1011-1021 Jul 2010.  The 12 degrees and 20 degrees domain rotations indicate motions that occur during the ATP-coupled mechanism of the disassembly of pili into membrane-localized pilin monomers. Integrating these observations, we propose a three-state "Ready, Active, Release" model for the action of PilT.

Recent Artistic Works

 

Collaboration

 

Research Tools

 

Research Facilities

 

E-mail Address

forest@bact.wisc.edu 

Phone Number

(608) 265-3566 

Current University

UW - Madison 

Department

Bacteriology 

Title

Associate Professor 

Other Appointments

Chair, Information Technology Committee
Vice Director, Biotechnology Training Program
 

Address Line 1

6552 Microbial Sciences Building 

Address Line 2

1550 Linden Drive 

City

Madison 

State

WI 

Zip Code

53706 

Bachelor's Degree

BS, Massachusetts Institute of Technology, 1987

Master's Degree

 

PhD

PhD, Princeton University, 1993

Other Degrees

 

Technologies Available for Licensing

Attachments
Created at 6/12/2007 2:07 PM  by Mindy Dawson 
Last modified at 8/17/2011 10:54 AM  by EXTWEB\rshea