• Gates Foundation, 2008-2009, Elimination of HIV Infected Cells Via the Use of Antibody Targeted, Inductively Heated Nanoparticles
• Multiple Donors, 2003-2099, Imaging Research

• 6,699,507 - Colloidal particles of different element composition for specific labeling purposes, granted Mar 2004.
• 5,380,589 - Biotextured surfaces, granted Jan 1995.

• "Colloidal palladium particles of different shapes for electron microscopy labeling"

Meyer DA, Oliver JA, Albrecht RM, Microscopy and Microanalysis 16 (1):33-42 Feb 2010. In this study, we report the synthesis of colloidal palladium (cPd) nanoparticles of similar size but having two distinct shapes, umbonate and faceted, which are readily distinguishable from spherical colloidal gold particles. Their utility and Fidelity as labels using a human platelet whole-mount model is also demonstrated.

• "Toxicity Assessments of Multisized Gold and Silver Nanoparticles in Zebrafish Embryos"

Bar-llan O, Albrecht RM, Fako VE et al. Small 5(16): 1897-1910 August 2009. The potential toxicity of nanoparticles is addressed by utilizing a putative attractive model in developmental biology and genetics: the zebrafish (Danio rerio). Transparent zebrafish embryos, possessing a high degree of homology to the human genome, offer an economically feasible, medium-througput screening platform for noninvasive real-time assessments of toxicity.

• "A novel cell wall lipopeptide is important for biofilm formation and pathogenicity of Mycobacterium avium subspecies paratuberculosis"

Chia-Wei WA, Schmoller SK, Bannantine JP, et al., Microbial Pathogenesis 46 (4): 222-230 Apr 2009. The results revealed a novel cell wall component that could contribute to biofilm formation and to the virulence and immunogenicity of M. ap. Molecular tools to better control M. ap infections could be developed utilizing the presented findings. Keywords: Sliding Motility; Virulence; Biofilm Formation; Johnes Disease; Smegmatis; Tuberculosis; Dispersal; pstA; Immunogenicity.

• "Immuno-EM using colloidal metal nanoparticles and electron spectroscopic imaging for co-localization at high spatial resolution"

Bleher R, Kandela I, Meyer DA, et al., Journal of Microscopy-Oxford 230 (3): 388-395 Jun 2008. In the current study, we investigate a method for high-resolution multiple-labelling immuno-EM, using equally sized colloidal markers made of different metals. Energy filtering transmission electron microscopy is used to differentiate particles based on elemental composition.

• Intra-University Collaboration: Pathobiological Science, Lab for Bacterial Genomics, Surgical Science
• USDA ARS
• Colorado State University, Microbiology, Immunology, Pathology
• University of New Mexico

• Video-enhanced DIC light microscopy
• EFTEM
• STEM
• High resolution EDX and EELS
• Tomography high resolution imaging
• High resolution SEM

• BBPIC/AMFSC Microscopy Lab