Wisconsin Discovery Portal

Researcher's Profile

Last Name

Kaspar 

First Name

Charles 

Middle Initial

Areas of Research Expertise

* Focuses on microbial acid tolerance in acidophilic archea and fungi to neutrophiles like E. Coli with emphasis on identifying and defining the function of proteins that afford protection to biomolecules
* Current projects examine factors contributing to E. coli shedding in cattle
* Mechanisms of acid tolerance in E. coli and other microbes
* Regulation of dps - a key acid tolerance protein in E. coli
* The use of egg yolk anti 0157:H7 immunoglobulin to clear E. coli from the intestinal tract of cattle
* Acidophiles
* Microbial ecology
* Host-pathogen interactions
* Antibiotic resistance

Web site

Charles Kaspar's University Web Page 

Curriculum Vitae (CV)

 

Current/Active Funding

 

Issued Patent(s)

 

USPTO Published Applications

Recent Publication(s)

  • "Production of methanethiol and volatile sulfur compounds by the archaeon "Ferroplasma acidarmanus"

Baumler DJ, Hung KF, Jeong KC, et al., Extremophiles 11 (6): 841-851 Nov 2007. Collectively, these data demonstrate that "F. acidarmanus" produces methanethiol through the metabolism of methionine, cysteine, or sulfate. This is the first report of a methanethiol-producing acidophile, thus identifying a new contributor to the global sulfur cycle.

  • "Isolation of Escherichia coli O157 : H7 from the gall bladder of inoculated and naturally-infected cattle"
Jeong KC, Kang MY, Heimke C, et al., Veterinary Microbiology 119 (2-4): 339-345 Jan 2007. This study establishes that E. coli O157H7 can reside transiently or permanently at a low level in the gall bladder of cattle.
  • "H-NS controls metabolism and stress tolerance in Escherichia coli O157 : H7 that influence mouse passage"
Erol I, Jeong KC, Baumler DJ, et al., BMC Microbiology 6: Art No. 72 Aug 2006. These results expand the influence of H-NS on carbon and nitrogen metabolism and highlight its role in the ability of O157:H7 strains to respond to changing nutrients and conditions encountered in the environment and its hosts.
  • "Enhancement of acid tolerance in Zymomonas mobilis by a proton-buffering peptide"
Baumler DJ, Hung KF, Bose JL, et al., Applied Biochemistry and Biotechnology 134 (1): 15-26 Jul 2006. Results from this study demonstrate that the production of a peptide with a high proportion of basic amino acids can contribute to protection from low pH and weak organic acids such as acetic acid.

Recent Artistic Works

 

Collaboration

  • Food Research Institute

Research Tools

 

Research Facilities

 

E-mail Address

cwkaspar@wisc.edu 

Phone Number

(608) 263-6936 

Current University

UW- Madison 

Department

Animal Sciences / Bacteriology 

Title

Professor 

Other Appointments

 

Address Line 1

3470 Microbial Sciences Building 

Address Line 2

1550 Linden Drive 

City

Madison 

State

WI 

Zip Code

53706 

Bachelor's Degree

BS, University of Nebraska, Biology, 1980

Master's Degree

MS, Iowa State University, Microbiology, 1983

PhD

PhD, Iowa State University, Microbiology 1986

Other Degrees

 

Technologies Available for Licensing

Attachments
Created at 6/12/2007 2:07 PM  by Mindy Dawson 
Last modified at 12/1/2009 3:24 PM  by EXTWEB\alarson