Cezar GG, Quam JA, Smith AM, et al., Stem Cells and Development 16 (6): 869-882 Dec 2007. We hypothesized that small molecules could be measured from undifferentiated hES cells and hES cell-derived neural precursors (hNPs) using metabolomics and that these compounds are altered in response to known disruptors of human development.
Cezar GG, Current Opinion in Chemical Biology 11 (4): 405-409 Aug 2007. The pluripotency of embryonic stem cells, that is, the capacity to generate multiple cell types, is a novel path for the discovery of 'regenerative drugs', the pursuit of small molecules that promote tissue repair (neurogenesis, cardiogenesis) or proliferation of resident stem cells in different organs, thus creating drugs that work by a novel mechanism.