Wisconsin Discovery Portal

Researcher's Profile

Last Name

Kirkpatrick 

First Name

Brian 

Middle Initial

Areas of Research Expertise

* Interests include analysis of genetic variation in reproduction and disease resistance in livestock and laboratory species and refinement of bovine/human/mouse comparative map
* Primary focus is identification of genes (quantitative trait loci or QTL) contributing to a variation in bovine twinning rate
* Comparative mapping efforts are targeted to genomic regions harboring QTL and regions lacking comparative map data

Web site

Brian Kirkpatrick's University Home Page 

Curriculum Vitae (CV)

 

Current/Active Funding

  • Hatch Multi-State Research Formula Fund, 2008-2012, National Animal Genome Research Program

Issued Patent(s)

  • 5,759,772 - Method for determining the sex of an embryo, granted Jun 1998.

USPTO Published Applications

Recent Publication(s)

  • "Fine-mapping quantitative trait loci for twinning rate on Bos taurus chromosome 14 in North American Holsteins"

Bierman CD, Kim E, Weigel K, Berger PJ, Kirkpatrick BW, Journal of Animal Science 88(8): 2556-2564 Aug 2010.  Based on single-marker results from data II, BTA14 harbors QTL responsible for approximately 24% of the variation in twinning rate predicted transmitting ability. 

  • "A cattle family in New Zealand with triplet calving abilities"

Morris CA, Wheeler M, Levet GL, et al., Livestock Science 128 (1-3): 193-196 Mar 2010. This paper reports on calving data from a cow family in New Zealand which is elite for triplet calving ability. The foundation cow (named 'Treble') was born in 1993 and her calvings included three sets of triplets. A triplet son (named 'Trio'), born in 1996, was used for matings in two New Zealand herds, producing 44 daughters which were retained for breeding, and these had a total of 109 calvings by 2008.

  • "Geonme-wide scan for bovine twinning rate QTL using linkage disequilibrium"

Kim ES, Berger PJ, Kirkpatrick BW, Animal Genetics 40 (3): 300-307 Jun 2009. To identify genomic regions or genes associated with twinning rate, QTL analysis based on linkage combined with linkage disequilibrium ( LLD) and individual marker associations was conducted across the genome using high-throughput single nucleotide polymorphism ( SNP) genotypes. Keywords: Quantitative Trait Loci; Ovulation Rate QTL; Dense Marker Maps; Single Nucleotide Polymorphism; Twin.

  • "Linkage disequilibrium in the North American Holstein population"

Kim ES, Kirkpatrick BW, Animal Genetics 40 (3): 279-288 Jun 2009. Linkage disequilibrium was estimated using 7119 single nucleotide polymorphism markers across the genome and 200 animals from the North American Holstein cattle population. Keywords: Quantitative Trait Loci; Human genome; Haplotype Blocks; Cattle Breeds; Linkage Disequilibrium; Nucleotide Polymorphism.

  • "Refined mapping of twinning-rate quantitative trait loci on bovine chromosome 5 and analysis of insulin-like growth factor-1 as a positional candidate gene"

Kim ES, Shi X, Kirkpatrick BW, et al., Journal of Animal Science 87 (3): 835-843 Mar 2009. Using a large number of animals, an increased density of SNP marker association tests, and a combined linkage and linkage disequilibrium mapping method, the position of QTL was defined in the North American Holstein population. Keywords: Ovulation Rate; Cattle; Prediction; Genome; Linkage; Identity; Map.

Recent Artistic Works

 

Collaboration

  • Iowa State University, Animal Sciences

Research Tools

 

Research Facilities

 

E-mail Address

bwkirkpa@wisc.edu 

Phone Number

(608) 263-4323 

Current University

UW- Madison 

Department

Animal Sciences 

Title

Professor 

Other Appointments

Director, Twinning Cattle Project
Affiliate Professor, Dairy Science

Address Line 1

646 Animal Science Building 

Address Line 2

1675 Observatory Drive 

City

Madison 

State

WI 

Zip Code

53706 

Bachelor's Degree

BS, Iowa State University, Animal Science, 1979

Master's Degree

MS, University of Wisconsin-Madison, Meat & Animal Sciences/Animal Breeding, 1984

PhD

PhD, University of Wisconsin-Madison, Meat & Animal Sciences/Animal Breeding, 1987

Other Degrees

 

Technologies Available for Licensing

Attachments
Created at 6/12/2007 2:06 PM  by Mindy Dawson 
Last modified at 8/4/2010 2:53 PM  by EXTWEB\alarson