- "mosR a novel transcriptional regulator of hypoxia and virulence in mycobacterium tuberculosis"
Abomoelak B, Hoye EA, Chi J, et al., Journal of Bacteriology 191 (19): 5941-5952 Oct 2009. Taken together, our analyses indicated that the Rv0348 gene encodes a novel transcriptional factor that regulates several operons involved in mycobacterial survival, especially during hypoxia; hence, we propose that Rv0348 be renamed mosR for regulator of mycobacterial operons of survival.
- "The global responses of Mycobacterium tuberculosis to physiological levels of copper"
Ward SK, Hoye EA, Talaat AM, Journal of Bacteriology 190 (8): 2939-2946 Apr 2008. In this study, we showed that ctpV, a gene in the cso operon, is a copper-responsive gene and most likely encodes an efflux pump for Cu. Furthermore, the transcription of key genes in the cso operon is induced by Cu ions and not by other ions, such as Ni and Zn ions.
- "CsoR is a novel Mycobacterium tuberculosis copper-sensing transcriptional regulator"
Liu T, Ramesh A, Ma Z, et al., Nature Chemical Biology 3 (1): 60-68 Jan 2007. Here, we identify a new copper-specific repressor (CsoR) of a copper-sensitive operon (cso) in Mycobacterium tuberculosis (Mtb) that is representative of a large, previously uncharacterized family of proteins (DUF156). Potential roles of CsoR in Mtb pathogenesis are discussed.
- "Identification of novel virulence determinants in Mycobacterium paratuberculosis by screening a library of insertional mutants"
Shin SJ, Wu CW, Steinberg H, et al., Infection and Immunity 74 (7): 3825-3833 Jul 2006. The identified potential virulence determinants represent novel functional classes that could be necessary for mycobacterial survival during infection and could provide suitable targets for vaccine and drug development against Johne's and Crohn's diseases.