- "Genetic susceptibility to chronic wasting disease in free-ranging white-tailed deer: Complement component C1q and Prnp polymorphisms"
Blanchong JA, Heisey DM, Scribner KT, Libants SV, Johnson C, Aiken JM, Langenberg JA, Samuel MD, Infection Genetics and Evolution 9(6): 1329-1335 Dec 2009. After controlling for Prnp, we found weak support for an elevated risk of CWD infection in deer with at least one Glycine at amino acid 56 of the C1qC gene.
- "Surveillance for transmissible spongiform encephalopathy on scavengers of white-tailed deer carcasses in the Chronic Wasting Disease area of Wisconsin"
Jennelle CS, Samuel MD, Nolden CA, et al., Journal of Toxicology and Enviornmental Health-Part-A-Current Issues 72 (17-18): 1018-1024 2009. In this study tissues were tested from 812 representative mammalian scavengers, collected in the CWD-affected area of Wisconsin, for TSE infection using the IDEXX HerdChek enzyme-linked immunosorbent assay (ELISA).
- "Soil and the transmission of prion diseases"
Pedersen J, Johnson CJ, Aiken JM et al. Geochimica ET Cosmochimica ACTA 73(13): A1007-A1007 June 2009.
- "Comparative prion disease gene expression profiling using the prion disease mimetic, cuprizone"
Moody LR, Herbst AJ, Yoo HS, et al., Prion 3 (2): 99-109 Apr-Jun 2009. In this study, expression profiles from the brains of mice preclinically and clinically infected with Rocky Mountain Laboratory (RML) mouse-adapted scrapie agent and age-matched controls were profiled using Affymetrix gene arrays. In total, 164 genes were differentially regulated during prion infection.
- "Persistence of pathogenic prion protein during simulated wastewater treatment processes"
Hinckley GT, Johnson CJ, Jacobson KH, et al., Environmental Science & Technology 42 (14): 5254-5259 Jul 2008. Here, we report the results of experiments examining the partitioning and persistence of PrPTSE during simulated wastewater treatment processes including activated and mesophilic anaerobic sludge digestion. Incubation with activated sludge did not result in significant PrPTSE degradation. PrPTSE and prion infectivity partitioned strongly to activated sludge solids and are expected to enter biosolids treatment processes.